Intercellular cannibalism fuels tumor growth
نویسندگان
چکیده
منابع مشابه
Intercellular Communication, the Tumor Microenvironment, and Tumor Progression
Within a solid tumor, cancer cells interact with normal host cells as well as with insoluble and soluble factors, including extracellular matrix proteins and chemokines. Here, we survey the molecular mechanisms by which cancer cells interact with their surrounding microenvironment, with a particular focus on intercellular communication. This host-tumor crosstalk provides key signals that direct...
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Because serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) are elevated in cancer and sICAM-1 is angiogenic, we tested the ability of sICAM-1 to promote tumor growth. Our preliminary experiments showed that exogenous sICAM-1 significantly stimulated the growth of human tumors in vivo. Human fibrosarcoma transfectants, which express ICAM-1, produce ICAM-1 on the cell surface and...
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Mechanical force regulates the formation and growth of cell-cell junctions. Cadherin is a prominent homotypic cell adhesion molecule that plays a crucial role in establishment of intercellular adhesion. It is known that the transmitted force through the cadherin-mediated junctions directly correlates with the growth and enlargement of the junctions. In this paper, we propose a physical model fo...
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This essay discusses the image and practice of cannibalism in a wide range of studies. It also presents the anthropological research on kuru which led to the proposal that cannibalism had enabled transmission of the infectious agent, as well as doubts about the hypothesis, and the assertion by some that cannibalism as a socially approved custom did not exist. The figure of the cannibal as an ic...
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2017
ISSN: 1350-9047,1476-5403
DOI: 10.1038/cdd.2017.39